Permethrin

Definition

A synthetic pyrethroid and neurotoxin. Permethrin affects the neuronal membrane by blocking the movement of sodium ions from outside to inside the neuronal cell membrane thereby disrupting the sodium channel current that regulates the polarization of the membrane. This leads to delayed repolarization and subsequent paralysis of the nervous system. Permethrin is used to eradicate parasites such as head lice, ticks and scabies from humans and animals.

NCIT:C29354 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as (+/-)-3-Phenoxybenzyl 3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate, Cyclopropanecarboxylic Acid, 3-(2,2-Dichloroethenyl)-2,2-Dimethyl-, (3-Phenoxyphenyl)Methyl Ester, Elimite, M-Phenoxybenzyl (+/-)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarboxylate, Nix, PERMETHRIN — per NCIT

Also identified as

ATC P03AC04 per RXNORM
NCIT NCIT:C29354 per NCIT
SCTID 1887004 per RXNORM
SCTID 410457007 per RXNORM
UNII 509F88P9SZ per RXNORM

Indications

Disease	Relation	Source
Lice infestation	may prevent	MEDRT · Public domain (U.S. Government work)
Lice infestation	may treat	MEDRT · Public domain (U.S. Government work)
Scabies	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Skin of body	may treat a disease of this organ	DERIVED · CC BY 4.0

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.