Phenyltoloxamine
Phenyltoloxamine
Definition
An ethanolamine derivative with antihistaminic property. Phenyltoloxamine blocks H1 histamine receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of guanylyl cyclase through nitric oxide results in decreased cyclic GMP levels, thereby inhibiting smooth muscle constriction of various tissues, decreasing capillary permeability and decreasing other histamine-activated allergic reactions.
Also known as Antin, Bristamin, Histionex, N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamine, N,N-Dimethyl-2-(alpha-phenyl-o-tolyloxy)ethylamine, PHENYLTOLOXAMINE — per NCIT
Also identified as
- NCIT NCIT:C47669 per NCIT
- SCTID 387215006 per RXNORM
- SCTID 39939003 per RXNORM
- UNII K65LB6598J per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Perennial allergic rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Urticaria | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.