Pramocaine
Pramocaine
Definition
A morpholine derivative with local anesthetic property. Pramocaine decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.
Also known as 4-(3-(p-Butoxyphenoxy)propyl)morpholine, Pramocaine, PRAMOXINE — per NCIT
Also identified as
- ATC C05AD07 per RXNORM
- ATC D04AB07 per RXNORM
- NCIT NCIT:C61903 per NCIT
- SCTID 31872002 per RXNORM
- SCTID 387175007 per RXNORM
- UNII 068X84E056 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Contact dermatitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Hemorrhoids | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Anus | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.