Quazepam

Definition

A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability.

Also known as 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-, Doral, Dormalin, QUAZEPAM, Selepam — per NCIT

Also identified as

• ATC N05CD10 per RXNORM
• NCIT NCIT:C47699 per NCIT
• SCTID 108391004 per RXNORM
• SCTID 371372004 per RXNORM
• UNII JF8V0828ZI per RXNORM

Indications