Sertaconazole

Definition

A synthetic imidazole derivative, containing a benzothiophene ring, with antifungal, antibacterial, anti-inflammatory and anti-pruritic activity. Besides its ability to inhibit the synthesis of ergosterol, the benzothiophene ring of sertaconazole is able to insert into the fungal cell wall instead of tryptophan. This increases the permeability of the cell wall. In addition, sertaconazole suppresses the release of cytokines.

Also known as [R,S]-(+/-)-1-{2,4-Dichlor-beta-[(7-chlorbenzo[b]thien-3-yl)methoxy]phenethyl}imidazol, SERTACONAZOLE — per NCIT

Also identified as

• ATC D01AC14 per RXNORM
• ATC G01AF19 per RXNORM
• NCIT NCIT:C75206 per NCIT
• SCTID 409280001 per RXNORM
• SCTID 409281002 per RXNORM
• UNII 72W71I16EG per RXNORM

Indications