Vinorelbine
Vinorelbine
Definition
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
Also known as 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine, 5'-Nor-Anhydrovinblastine, Dihydroxydeoxynorvinkaleukoblastine, nor-5'-Anhydrovinblastine, VINORELBINE — per NCIT
Also identified as
- ATC L01CA04 per RXNORM
- NCIT NCIT:C1275 per NCIT
- SCTID 108792008 per RXNORM
- SCTID 372541004 per RXNORM
- UNII Q6C979R91Y per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ovarian cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.