Pyrithione Zinc

Definition

A coordination complex of the zinc ion and pyrithione, a derivative of the naturally occurring antibiotic aspergillic acid with antimicrobial, antifungal and anti-seborrheic effects. Although the exact mechanism of action remains to be fully elucidated, pyrithione zinc appears to interfere with the membrane transport of ions and metabolites, ultimately leading to a loss of metabolic control. In addition, this agent causes an influx of copper, leading to a reduction in the activity of iron-sulphur proteins resulting in growth inhibition.

Also known as 2-Mercaptopyridine 1-oxide Zinc Salt, Bis(1-hydroxy-2(1H)-pyridinethionato)zinc, PYRITHIONE ZINC, Zinc Pyridine-2-thiol 1-oxide, Zinc Pyrithione, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, Zinc, bis(2-pyridylthio)-, N,N'-dioxide — per NCIT

Also identified as

• ATC D11AX12 per RXNORM
• NCIT NCIT:C47698 per NCIT
• SCTID 255954005 per RXNORM
• SCTID 411297004 per RXNORM
• UNII R953O2RHZ5 per RXNORM

Indications

Organ Effects

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.