Zonisamide

Definition

A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.

NCIT:C47790 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 1,2-Benzisoxazole-3-methanesulfonamide, Excegram, Zonegran, ZONISAMIDE — per NCIT

Also identified as

ATC N03AX15 per RXNORM
NCIT NCIT:C47790 per NCIT
SCTID 125693002 per RXNORM
SCTID 398762003 per RXNORM
UNII 459384H98V per RXNORM

Indications

Disease	Relation	Source
Focal epilepsy	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Brain	may treat a disease of this organ	DERIVED · CC BY 4.0
Central nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0
Nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.