Iloprost

Definition

A prostacyclin analogue with potential chemopreventive activity. Iloprost binds to the prostacyclin receptor in various target cells, thereby causing vasodilation, inhibition of platelet aggregation, and decreased tumor cell adhesion to endothelium among other effects. Prostacyclin is a naturally occurring eicosanoid with anti-inflammatory, antineoplastic, and anti-metastatic properties. (NCI05)

Also known as (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid, Ciloprost, ILOPROST, Iloprost Clathrate, Pentanoic Acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, Ventavis, ZK 36374 — per NCIT

Also identified as

• ATC B01AC11 per RXNORM
• NCIT NCIT:C48397 per NCIT
• SCTID 319452005 per RXNORM
• SCTID 395740002 per RXNORM
• UNII JED5K35YGL per RXNORM

Indications