Fluvastatin
Fluvastatin
Definition
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.
Also known as FLUVASTATIN — per NCIT
Also identified as
- ATC C10AA04 per RXNORM
- NCIT NCIT:C61768 per NCIT
- SCTID 387585004 per RXNORM
- SCTID 96307003 per RXNORM
- UNII 4L066368AS per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Coronary artery disorder | may prevent | MEDRT · Public domain (U.S. Government work) |
| Coronary artery disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Hyperlipoproteinemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypertriglyceridemia | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.