Halobetasol

Definition

A synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via the corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.

Also known as HALOBETASOL — per NCIT

Also identified as

• ATC D07AC21 per RXNORM
• NCIT NCIT:C61781 per NCIT
• SCTID 764616008 per RXNORM
• SCTID 764617004 per RXNORM
• UNII 9P6159HM7T per RXNORM

Indications