Fluvoxamine

Definition

A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro.

Also known as FLUVOXAMINE — per NCIT

Also identified as

• ATC N06AB08 per RXNORM
• NCIT NCIT:C61769 per NCIT
• SCTID 372905008 per RXNORM
• SCTID 96213009 per RXNORM
• UNII O4L1XPO44W per RXNORM

Indications