Clofarabine

Definition

A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis.

Also known as 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine, 2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine, CLOFARABINE, Clofarex, Clolar — per NCIT

Also identified as

• ATC L01BB06 per RXNORM
• NCIT NCIT:C26638 per NCIT
• SCTID 413873006 per RXNORM
• SCTID 417601005 per RXNORM
• UNII 762RDY0Y2H per RXNORM

Indications

Organ Effects

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.