Dofetilide
Dofetilide
Definition
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
Also known as beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide, DOFETILIDE, Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-, Tikosyn — per NCIT
Also identified as
- ATC C01BD04 per RXNORM
- NCIT NCIT:C47499 per NCIT
- SCTID 116107002 per RXNORM
- SCTID 392658005 per RXNORM
- UNII R4Z9X1N2ND per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Atrial fibrillation | may treat | MEDRT · Public domain (U.S. Government work) |
| Atrial flutter | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.