Histrelin

Definition

A long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production.

Also known as HISTRELIN — per NCIT

Also identified as

• ATC L02AE05 per RXNORM
• NCIT NCIT:C74270 per NCIT
• SCTID 109049002 per RXNORM
• SCTID 126198004 per RXNORM
• UNII H50H3S3W74 per RXNORM

Indications