Loteprednol Etabonate
Loteprednol Etabonate
Definition
The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes.
Also known as Alrex, Androsta-1,4-diene-17-carboxylic Acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl Ester,(11beta,17alpha)-, Lotemax, LOTEPREDNOL ETABONATE — per NCIT
Also identified as
- NCIT NCIT:C47589 per NCIT
- SCTID 387047007 per RXNORM
- UNII YEH1EZ96K6 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial conjunctivitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Iritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Keratitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rosacea | may treat | MEDRT · Public domain (U.S. Government work) |
| Viral conjunctivitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Conjunctiva | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cornea | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Ocular adnexa | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
6 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.