Paclitaxel
Paclitaxel
Definition
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)
Also known as 5Beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine, Anzatax, Asotax, Bristaxol, PACLITAXEL, Praxel, Taxol, Taxol Konzentrat — per NCIT
Also identified as
- ATC L01CD per NCIT
- NCIT NCIT:C1411 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Kaposi's sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ovarian cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Blood vessel | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.