Collagenase Clostridium histolyticum

Definition

A therapeutic enzyme produced by the bacterium Clostridium histolyticum, with enzymatic debriding activity. Upon injection of collagenase clostridium histolyticum to the affected area(s), the collagenase hydrolyzes collagen in the collagen triple helix structure resulting in lysis and solubilization of collagen deposits and plaques. This may promote healing and reduce symptoms caused by excessive collagen deposits and accumulation, such as stiffness of the tissue and pain.

Also known as C. Clostridium histolyticum EN3835, CCH EN3835, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, Collagenase Clostridium histolyticum EN3835, EN 3835, EN-3835, EN3835, Xiaflex — per NCIT

Also identified as

• ATC D03BA02 per RXNORM
• NCIT NCIT:C185860 per NCIT
• SCTID 417416003 per RXNORM
• SCTID 772213007 per RXNORM
• UNII 9X7O8V25IT per RXNORM

Indications