Penciclovir
Penciclovir
Definition
A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.
Also known as 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-, 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, BRL 39123, BRL-39123, CCRIS 9213, Denavir, PENCICLOVIR — per NCIT
Also identified as
- ATC D06BB06 per RXNORM
- ATC J05AB13 per RXNORM
- NCIT NCIT:C66337 per NCIT
- SCTID 108918003 per RXNORM
- SCTID 386939003 per RXNORM
- UNII 359HUE8FJC per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Epstein-Barr virus infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Herpes labialis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.