Docetaxel
Docetaxel
Definition
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)
Also known as Docecad, DOCETAXEL, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate — per NCIT
Also identified as
- ATC L01CD per NCIT
- NCIT NCIT:C1526 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastric neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Melanoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ovarian cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Pancreatic neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Prostate cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.