Bivalirudin

Definition

A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina.

Also known as BIVALIRUDIN, Hirulog, L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl- — per NCIT

Also identified as

• ATC B01AE06 per RXNORM
• NCIT NCIT:C47415 per NCIT
• SCTID 129498009 per RXNORM
• SCTID 400610005 per RXNORM
• UNII TN9BEX005G per RXNORM

Indications