Vincristine
Vincristine
Definition
A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
Also known as 22-Oxovincaleukoblastine, LCR, LEUROCRISTINE, VCR, VINCRISTINE, Vincrystine — per NCIT
Also identified as
- ATC L01CA per NCIT
- NCIT NCIT:C933 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Neuroblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-Hodgkin lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Rhabdomyosarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Wilms tumor | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Striated muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.