Pemetrexed
Pemetrexed
Definition
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.
Also known as L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl), MTA, Multitargeted Antifolate, PEMETREXED, Pemfexy — per NCIT
Also identified as
- ATC L01BA04 per RXNORM
- NCIT NCIT:C61614 per NCIT
- SCTID 409159000 per RXNORM
- SCTID 411089001 per RXNORM
- UNII 04Q9AIZ7NO per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Lung neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Mesothelial neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Mesothelioma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.