Zanamivir

Definition

A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication.

Also known as 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid, 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid, GANA, GG 167, Relenza, ZANAMIVIR — per NCIT

Also identified as

• ATC J05AH01 per RXNORM
• NCIT NCIT:C47786 per NCIT
• SCTID 116100000 per RXNORM
• SCTID 387010007 per RXNORM
• UNII L6O3XI777I per RXNORM

Indications