Raloxifene

Definition

A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. (NCI04)

Also known as [6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone, Keoxifene, LY 139481, RALOXIFENE — per NCIT

Also identified as

• ATC G03XC01 per RXNORM
• NCIT NCIT:C1518 per NCIT
• SCTID 109029006 per RXNORM
• SCTID 419530003 per RXNORM
• UNII YX9162EO3I per RXNORM

Indications