Tirofiban
Tirofiban
Definition
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time.
Also known as TIROFIBAN — per NCIT
Also identified as
- ATC B01AC17 per RXNORM
- NCIT NCIT:C76405 per NCIT
- SCTID 108981004 per RXNORM
- SCTID 386953003 per RXNORM
- UNII GGX234SI5H per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Ischemic heart disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Stroke | may prevent | MEDRT · Public domain (U.S. Government work) |
| Intermediate coronary syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Myocardial infarction | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculature | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Myocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.