Bosentan

Definition

A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.

Also known as 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide, BOSENTAN, Bosentan Monohydrate, Ro 47-0203, Tracleer — per NCIT

Also identified as

• ATC C02KX01 per RXNORM
• NCIT NCIT:C47417 per NCIT
• SCTID 385558007 per RXNORM
• SCTID 385559004 per RXNORM
• UNII Q326023R30 per RXNORM

Indications