Cidofovir

Definition

A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.

Also known as 1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine, CDV, CIDOFOVIR, Cidofovir Dihydrate, DRG-0145, GS-0504, HPMPC, Vistide — per NCIT

Also identified as

• ATC J05AB12 per RXNORM
• NCIT NCIT:C1600 per NCIT
• SCTID 108688007 per RXNORM
• SCTID 386894007 per RXNORM
• UNII JIL713Q00N per RXNORM

Indications

Organ Effects

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.