Irbesartan
Irbesartan
Definition
A nonpeptide angiotensin II antagonist with antihypertensive activity. Irbesartan selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. (NCI05)
Also known as Avapro, IRBESARTAN — per NCIT
Also identified as
- ATC C09CA04 per RXNORM
- NCIT NCIT:C29130 per NCIT
- SCTID 108585000 per RXNORM
- SCTID 386877005 per RXNORM
- UNII J0E2756Z7N per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Diabetic kidney disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypertensive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Adult mammalian kidney | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.