Diflorasone

Definition

A synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE). Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes.

Also known as DIFLORASONE — per NCIT

Also identified as

• ATC D07AC10 per RXNORM
• NCIT NCIT:C61722 per NCIT
• SCTID 772931004 per RXNORM
• SCTID 7924004 per RXNORM
• UNII T2DHJ9645W per RXNORM

Indications