Mometasone
Mometasone
Definition
A synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.
Also known as MOMETASONE — per NCIT
Also identified as
- ATC D07AC13 per RXNORM
- ATC D07XC03 per RXNORM
- ATC R01AD09 per RXNORM
- ATC R03BA07 per RXNORM
- NCIT NCIT:C66181 per NCIT
- SCTID 395990009 per RXNORM
- SCTID 75203002 per RXNORM
- UNII 8HR4QJ6DW8 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Facial dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Hand dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Leg dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Perennial allergic rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Scalp dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.