Becaplermin

Definition

The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF). Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B. PDGF functions as a local autocrine and paracrine growth factor in many cellular processes. Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04)

Also known as BECAPLERMIN, PDGF Beta Chain, Platelet-Derived Growth Factor Beta Chain, Platlet-Derived Growth Factor Beta Chain, Recombinant Platelet Derived Growth Factor Beta Chain, Regranex, rhPDGF-BB — per NCIT

Also identified as

• ATC A01AD08 per RXNORM
• ATC D03AX06 per RXNORM
• NCIT NCIT:C1668 per NCIT
• SCTID 108936003 per RXNORM
• SCTID 386940001 per RXNORM
• UNII 1B56C968OA per RXNORM

Indications