Tolterodine

Definition

A benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects.

Also known as TOLTERODINE — per NCIT

Also identified as

• ATC G04BD07 per RXNORM
• NCIT NCIT:C62083 per NCIT
• SCTID 109113000 per RXNORM
• SCTID 372570008 per RXNORM
• UNII WHE7A56U7K per RXNORM

Indications