Bendamustine
Bendamustine
Definition
A bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. Although the exact mechanism of action of bendamustine is unknown, this agent appears to alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and eventually the induction of apoptosis.
Also known as 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric Acid, BENDAMUSTINE, SDX 105, SDX-105, SDX105 — per NCIT
Also identified as
- ATC L01AA09 per RXNORM
- NCIT NCIT:C73261 per NCIT
- SCTID 427812009 per RXNORM
- SCTID 428012008 per RXNORM
- UNII 9266D9P3PQ per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Lymphoid leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-Hodgkin lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.