Gemifloxacin
Gemifloxacin
Definition
A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.
Also known as GEMIFLOXACIN — per NCIT
Also identified as
- ATC J01MA15 per RXNORM
- NCIT NCIT:C61775 per NCIT
- SCTID 407086007 per RXNORM
- SCTID 407087003 per RXNORM
- UNII OKR68Y0E4T per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bronchitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Gram-negative bacterial infections | may treat | MEDRT · Public domain (U.S. Government work) |
| Streptococcal pneumonia | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.