Levothyroxine
Levothyroxine
Definition
A synthetic levoisomer of thyroxine (T4), similar to the endogenous hormone produced by the thyroid gland. Thyroxine is de-iodinated to form triiodothyronine (T3) in the peripheral tissues. T3 enters the cell and binds to nuclear thyroid hormone receptors, and the hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration, thermogenesis, cellular growth and differentiation, and metabolism of proteins, carbohydrates and lipids. T4 and T3 also possess cardiac stimulatory effect.
Also known as (-)-Thyroxine, L-Thyroxine, LEVOTHYROXINE — per NCIT
Also identified as
- ATC H03AA per NCIT
- NCIT NCIT:C62080 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Hypothyroidism | may prevent | MEDRT · Public domain (U.S. Government work) |
| Autoimmune thyroid disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Goiter | may treat | MEDRT · Public domain (U.S. Government work) |
| Myxedema | may treat | MEDRT · Public domain (U.S. Government work) |
| Thyrotoxicosis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Neck | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Thyroid gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.