Sevelamer

Definition

A non-absorbable polymeric amine and phosphate binding agent that can be used to prevent hyperphosphatemia. Upon oral administration, the amine groups in sevelamer become protonated in the intestines and bind to the dietary phosphate groups in the gastrointestinal (GI) tract, thereby preventing the absorption of phosphate and controlling phosphate plasma levels. In addition, sevelamer, as a phosphate binder, can be used to prevent the absorption of the radionuclide phosphorus P 32 (P-32).

Also known as 2-Propen-1-amine, Polymer with (Chloromethyl)oxirane, Allylamine Polymer with 1-Chloro-2,3-epoxypropane, Allylamine-epichlorohydrin Copolymer, SEVELAMER — per NCIT

Also identified as

• ATC V03AE02 per RXNORM
• NCIT NCIT:C84172 per NCIT
• SCTID 329195003 per RXNORM
• SCTID 395871000 per RXNORM
• UNII 941N5DUU5C per RXNORM

Indications