Tenecteplase

ATC Code B01AD11

Tenecteplase

Definition

A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction.

Also known as TENECTEPLASE, TNK-tPA, TNKase — per NCIT

Also identified as

Indications

Disease Relation Source
Coronary thrombosis may treat MEDRT · Public domain (U.S. Government work)
Myocardial infarction may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Cardiovascular system may treat a disease of this organ DERIVED · CC BY 4.0
Heart may treat a disease of this organ DERIVED · CC BY 4.0
Musculature may treat a disease of this organ DERIVED · CC BY 4.0
Musculoskeletal system may treat a disease of this organ DERIVED · CC BY 4.0
Myocardium may treat a disease of this organ DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.