Nelarabine

Definition

An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)

Also known as 2-Amino-6-methoxypurine arabinoside, 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, 2-Amino, 6-Methoxypurine Arabinoside, 506U78, Arranon, Compound 506U78, GW506U78, NELARABINE — per NCIT

Also identified as

• ATC L01BB07 per RXNORM
• NCIT NCIT:C1704 per NCIT
• SCTID 418538001 per RXNORM
• SCTID 418784008 per RXNORM
• UNII 60158CV180 per RXNORM

Indications