Emtricitabine

Definition

A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group).

Also known as (-)-2'-Deoxy-5-fluoro-3'-thiacytidine, 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-, BW-524W91, Coviracil, dOTFC, EMTRICITABINE, Emtriva, FTC — per NCIT

Also identified as

• ATC J05AF09 per RXNORM
• NCIT NCIT:C47509 per NCIT
• SCTID 404855005 per RXNORM
• SCTID 404856006 per RXNORM
• UNII G70B4ETF4S per RXNORM

Indications