Almotriptan

Definition

A sulfonamide triptan with extracerebral, intracranial vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing extracerebral, intracranial blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

Also known as ALMOTRIPTAN — per NCIT

Also identified as

• ATC N02CC05 per RXNORM
• NCIT NCIT:C65224 per NCIT
• SCTID 134529000 per RXNORM
• SCTID 363569003 per RXNORM
• UNII 1O4XL5SN61 per RXNORM

Indications