Posaconazole
ATC Code
J02AC04
Posaconazole
Definition
A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase.
Also known as Noxafil, POSACONAZOLE, SCH 56592 — per NCIT
Also identified as
- ATC J02AC04 per RXNORM
- NCIT NCIT:C61500 per NCIT
- SCTID 420282006 per RXNORM
- SCTID 421747003 per RXNORM
- UNII 6TK1G07BHZ per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Aspergillosis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Candidiasis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Oral candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |