Esomeprazole

ATC Code A02BC05

Esomeprazole

Definition

The S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.

Also known as ESOMEPRAZOLE — per NCIT

Also identified as

Indications

Disease Relation Source
Gastric ulcer may prevent MEDRT · Public domain (U.S. Government work)
Duodenal ulcer may treat MEDRT · Public domain (U.S. Government work)
Esophagitis may treat MEDRT · Public domain (U.S. Government work)
Gastroesophageal reflux disease may treat MEDRT · Public domain (U.S. Government work)
Helicobacter pylori infectious disease may treat MEDRT · Public domain (U.S. Government work)
Zollinger-Ellison syndrome may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Alimentary part of gastrointestinal system may treat a disease of this organ DERIVED · CC BY 4.0
Esophagus may treat a disease of this organ DERIVED · CC BY 4.0
Intestine may treat a disease of this organ DERIVED · CC BY 4.0
Small intestine may treat a disease of this organ DERIVED · CC BY 4.0
Upper digestive tract may treat a disease of this organ DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.