Entecavir

Definition

A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.

Also known as 6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)- Monohydrate, 9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)Guanine Monohydrate, Baraclude, BMS-200475-01, ENTECAVIR, ETV, SQ-34676, SQ34676 — per NCIT

Also identified as

• ATC J05AF10 per RXNORM
• NCIT NCIT:C65513 per NCIT
• SCTID 416248007 per RXNORM
• SCTID 416644000 per RXNORM
• UNII 5968Y6H45M per RXNORM

Indications