Micafungin

Definition

A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death.

Also known as FK463, MICAFUNGIN — per NCIT

Also identified as

• ATC J02AX05 per RXNORM
• NCIT NCIT:C1850 per NCIT
• SCTID 416127003 per RXNORM
• SCTID 416233001 per RXNORM
• UNII R10H71BSWG per RXNORM

Indications