Adalimumab
Adalimumab
Definition
A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.
Also known as ABP 501, ADALIMUMAB, Adalimumab Biosimilar ABP 501, D2E7, Humira, Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer, LU200134 — per NCIT
Also identified as
- ATC L04AB04 per RXNORM
- NCIT NCIT:C65216 per NCIT
- SCTID 398728003 per RXNORM
- SCTID 407317001 per RXNORM
- UNII FYS6T7F842 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Ankylosing spondylitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Crohn's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Hidradenitis suppurativa | may treat | MEDRT · Public domain (U.S. Government work) |
| Juvenile idiopathic arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Psoriatic arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Ulcerative colitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Uveitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Uvea | may treat a disease of this organ | DERIVED · CC BY 4.0 |
7 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.