Ixabepilone

Definition

An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.

Also known as (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, Azaepothilone B, BMS 247550, BMS-247550, BMS247550, Epothilone, Epothilone-B BMS 247550, IXABEPILONE, Ixempra — per NCIT

Also identified as

• ATC L01DC04 per RXNORM
• NCIT NCIT:C37452 per NCIT
• SCTID 428282007 per RXNORM
• SCTID 429022006 per RXNORM
• UNII K27005NP0A per RXNORM

Indications