Tadalafil
ATC Code
G04BE08
Tadalafil
Definition
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
Also known as (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione, Cialis, Ic351, TADALAFIL — per NCIT
Also identified as
- ATC G04BE08 per RXNORM
- NCIT NCIT:C47743 per NCIT
- SCTID 407111005 per RXNORM
- SCTID 407734006 per RXNORM
- UNII 742SXX0ICT per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Pulmonary hypertension | may treat | MEDRT · Public domain (U.S. Government work) |
| Vasculogenic impotence | may treat | MEDRT · Public domain (U.S. Government work) |