Etravirine

Definition

A diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT.

Also known as 4-(6-Amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, ETRAVIRINE, ETV, Intelence, TMC-125 — per NCIT

Also identified as

• ATC J05AG04 per RXNORM
• NCIT NCIT:C73195 per NCIT
• SCTID 432121008 per RXNORM
• SCTID 432221004 per RXNORM
• UNII 0C50HW4FO1 per RXNORM

Indications