Lapatinib

Definition

A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.

Also known as GSK572016, GW 2016, GW 572016, GW-572016, GW2016, GW572016, LAPATINIB — per NCIT

Also identified as

• ATC L01EH01 per RXNORM
• NCIT NCIT:C26653 per NCIT
• SCTID 425466009 per RXNORM
• SCTID 425820005 per RXNORM
• UNII 0VUA21238F per RXNORM

Indications